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APHY102 CH. 21: Water, Electrolyte, and Acid-Base Balance

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  • October 1, 2022
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The bicarbonate, ________________ and ________________ buffer systems are the three major chemical buffer systems of the body.

phosphate, protein

The hormone called ____________ increases sodium re-absorption from the kidney tubules.

aldosterone

Home

Indicate the names of the two major fluid compartments of the body.

extracellular fluid, intracellular fluid

One way electrolytes are lost from the body is in _________.

sweat

Blood plasma and tissue fluid normally has a pH from __________ to ___________.

7.35; 7.45

The chemical class called ________________________ function to increase urine output.

diuretics

Indicate the two physiological buffer systems.

respiratory system, renal system

The total solute concentration of a body fluid is called its __________________.

osmolarity

When lymph flow is blocked by a tumor, fluid cannot drain away. The resulting condition is called ____________.

edema

TRUE or FALSE: The primary regulator of water intake is thirst.

true

Tweets by EssaysPatrick

List two sources of water intake.

ingestion , cellular metabolism

IMPORTANT: A chemical that combines with excess acids or bases is called a ____________.

buffer

The _______________ fluid compartment includes all of the fluid found within the cells of the body.

intracellular

The area of the brain called the ____________________ is the site of osmoreceptors, providing the sensation of thirst.

hypothalamus

Indicate the mechanisms that are part of the body’s first line of defense against pH shifts.

bicarbonate buffer, protein buffer, phosphate buffer

The clinical condition in which the blood pH level is at 7.34 or lower is defined as _______________.

acidosis

Indicate three major cations that are required for nerve conduction, muscle contraction, and maintenance of the cell membrane potential.

potassium, sodium, calcium

The primary method of regulating water loss is by changing the volume of _________ that is produced.

urine

As water loss occurs in the body, what happens to the osmotic pressure of the extracellular fluid?

osmotic pressure of ECF increases

Indicate two mechanisms employed to maintain water and electrolyte balance.

replace lost water and electrolytes, excrete any excess water and electrolytes

Give two causes of edema.

blood lymphatic vessels, hypoproteinmia

The condition called ______________ is due to an acid-base imbalance in which the arterial blood pH is higher than 7.45.

alkalosis

Many disorders cause excess tissue fluid to accumulate. Excessive tissue fluid is called _________.

edema

Consuming too much water (water intoxication) dilutes the sodium in the blood, leading to a condition called __________________.

hyponatremia

What change in water balance results in an increase in the osmotic pressure in extracellular fluid?

output exceeds intake (water loss)

What are three conditions associated with thirst?

loss of water by the body, increased blood osmolarity, increased osmotic pressure of extracellular fluid

A(n) __________________________________ in water content of extracellular fluid leads to ___________________________ osmolarity of blood and the sensation of thirst.

decrease; increased

The _____________________ of a body fluid is defined as the concentration of dissolved particles in the fluid.

osmolarity

The fluid in the ______________________ fluid compartment has high concentrations of sodium, chloride, and calcium.

extracellular

List the four fluids that are part of the extracellular fluid compartment.

plasma, lymph, transcellular fluid, interstitial fluid

Decreased plasma protein production by the liver results in _______________________.

hypoproteinemia

Hyponatremia is a condition in which there is too little ___________________ in the blood.

sodium

Low carbon dioxide levels in body fluids results in a(n) ________________ in pH, which will then lead to a(n) ________________ in breathing rate.

increase; decrease

The respiratory system controls pH by controlling ___________________ and _____________________ levels.

carbon dioxide; carbonic acid

TRUE or FALSE: Some regulation of the hydrogen ion concentration in body fluids is carried out by the respiratory center.

true, the respiratory center regulates pH by controlling the rate and depth of breathing

Rank the fluid compartments from highest to lowest in protein content.

intracellular fluid, plasma, interstitial fluid

TRUE or FALSE: Even small changes in the quantities of hydrogen ions in body fluids can be devastating.

true

The two major fluid compartments of the body are the _____________________fluid compartment and the ________________ fluid compartment.

extracellular; intracellular

Electrolytes that release hydrogen ions are known as ______________.

acids

What is an important function of electrolytes in the extracellular fluid?

they control movement of the water between fluid compartments

Changes in kidney function alter water _______________, while the thirst center regulates water _________________.

output; intake

Acids that ionize less completely and therefore release fewer hydrogen ions are called _________ acids.

weak

When extracellular sodium concentrations change, water moves across cell membranes by the process of _________________.

osmosis

By regulating ____________________, the body regulates electrolyte input.

hunger and thirst

Even slight changes in ________________ or ______________ ion concentration can effect enzyme action.

hydroxide; hydrogen

The two major types of alkalosis are ______________ alkalosis and _______________ alkalosis.

respiratory; metabolic

When does electrolyte balance occur?

when the amount of electrolytes gained equals the amount lost

Many patients with an excess of body fluid are prescribed a diuretic, which causes ____________________________.

increased urine output

Movement of water and electrolytes between fluid compartments is due to two factors: _________________ and _________________ pressure.

hydrostatic; osmotic

What is a base?

substance that removes hydrogen ions from solution

What is the largest of fluid intake?

ingestion of fluids

An acid-base buffer stabilizes pH by __________________ or _______________ as needed.

binding excess H+ or releasing H+

Oxidation of phosphorus-containing compounds such as nucleic acids would produce _________________ acid.

phosphoric

Since potassium is important in the repolarization phase of an electrical signal, what symptoms would you expect to see with hypokalemia?

muscle weakness

What is hypokalemia?

low potassium concentration in the blood

The increase in the use of sunscreens has the unintended consequence of decreasing vitamin D production. One symptom of vitamin D deficiency is ___________________________.

hypocalcemia

What is hyperkalemia?

higher than normal levels of potassium in the blood

When the pH of body fluids is low, kidney tubular cells make ammonia, which acts as a weak base to bind with ___________________ ions.

hydrogen

The primary stimulus to the respiratory centers in the brain are increasing levels of ______________ in the cerebrospinal fluid.

hydrogen ions

When the renal tubules actively re-absorb sodium, the anion _______________ follows passively.

chloride

Hyponatremia is a condition in which there is too little ________________ in the blood.

sodium

Ten percent of total water intake comes from ____________________.

metabolism

The term ___________________ refers to the “actions” taken by the various buffering systems to correct a pH change.

compensation

Which buffering system responds most rapidly?

chemical buffers

What is ascites?

fluid accumulation in the abdomen

Acidic ketone bodies resulting from the incomplete oxidation of fatty acids will __________________ hydrogen ion concentration in the body.

increase

Phosphoric acid is a byproduct of the breakdown of what compound?

nucleic acids

When electrolytes are depleted, one would crave ______________.

salty food

Accidental surgical removal of the parathyroid glands during a thyroidectomy (removal of the thyroid gland) would cause _____________________.

hypocalcemia

Why are the elderly more susceptible to dehydration than younger adults?

their thirst mechanisms are less sensitive

The term perspiration includes what route of water loss?

secretions from sweat glands

The compound called _______________ acid is a byproduct of the oxidation of sulfur-containing amino acids.

sulfuric

What is a cause of ascites?

blockage of the hepatic vein

The percent of total water intake that is from water of metabolism is ________%.

10

By what route does MOST water loss (output) occur?

urine excretion

An increase in cerebrospinal fluid levels of what chemical will stimulate the respiratory center of the brain?

carbon dioxide

The __________________ buffer system consists of the compound HPO4^-2 and H2PO4.

phosphate

Consuming too much water (water intoxication) dilutes the sodium in the blood, leading to a condition called ____________________________.

hyponatremia

Evaporation of water from the skin (NOT via sweat secretions) is classified as ______________ perspiration.

insensible

List three examples of transcellular fluids.

synovial fluid, cerebrospinal fluid, serous fluid in the body cavities

Excess tissue fluid in the abdomen causes swelling and pain. This abdominal swelling due to fluid accumulation is called _______________.

ascites

Why are infants more susceptible to dehydration than adults?

their kidneys are less efficient at conserving water

The activity of the hormone calcitonin results in a(n) ______________ in calcium levels.

decrease

Liver disease often results in a decrease in plasma protein concentration. The name for a low plasma protein level is _________________________________.

hypoproteinemia

Inhibiting ADH release causes ________________ water re-absorption and _________________urine output.

decreased; increased

Indicate two possible causes of hypokalemia.

diuretic drugs that increase potassium excretion, increased aldosterone secretion

One mole of sodium chloride yields ____________ osmole of dissolved particles.

two

In peripheral tissues, glucose metabolism produces carbon dioxide as a waste product, which then in turn causes an increase in the concentration of hydrogen ions. These hydrogen ions are buffered by _________________, a protein in red blood cells that is a part of the protein buffer system.

hemoglobin

The condition called __________________________ occurs when the body eliminates more water than it takes in.

dehydration

When sodium ions are actively reabsorbed in the renal tubules, _______________ ions are electrically attracted to them and follow passively.

chloride

Drowsiness and disorientation due to depression of CNS function, as well as breathing difficulty and cyanosis, are symptoms of __________________.

acidosis

Percentages of water by weight differ between males and females mainly because their bodies are composed of different amounts of __________ tissue.

fat

What force causes interstitial fluid to enter the lymphatic capillaries?

hydrostatic pressure of interstitial fluid

…

…

Some diuretic drugs increase the excretion of potassium in the kidneys, which causes ___________________.

hypokalemia

A condition in which the body temperature regulation fails is called ____________________. The body temperature increases above safe levels and organs start to fail.

heatstroke

An increase in the rate and depth of breathing will cause excretion of _________ carbon dioxide and therefore will _________________ hydrogen ion levels of body fluids.

more; decrease

Indicate two actions of the hormone calcitonin.

increases urinary excretion of calcium, stimulates bone formation

Hyperventilation leads to respiratory _________________.

alkalosis

Plasma that is _____________ concentrated than normal causes osmoreceptors to lose water and to signal the posterior pituitary gland to secrete ADH.

more

Drinking water decreases plasma osmolarity and ________________ the secretion of ADH.

decreases

In the extracellular fluid, 90% of the cations are ______________ ions

sodium

The loss of bicarbonate ions as a result of prolonged diarrhea may lead to ____________________.

metabolic acidosis

Name three factors that may lead to metabolic acidosis.

kidneys fail to excrete hydrogen ions, prolonged diarrhea with loss of intestinal secretions,excess production of ketones in diabetes mellitus

What are two symptoms of acidosis?

depression of the nervous system, cyanosis

Hyperkalemia causes which two symptoms?

skeletal muscle paralysis, cardiac disturbances

Where is the bicarbonate buffer system functional in maintaining acid/base balance?

in both the ECF and ICF

Instead of having the same composition throughout the body, fluids are found in regions called _____________, each of which may have a different composition.

compartments

Most changes in urine volume are linked to varying levels of the hormone called _________.

ADH

Fluid moves from the interstitial fluid into lymphatic capillaries due to ________________ pressure of the interstitial fluid.

hydrostatic

Indicate two proteins that can act as buffers as part of the protein buffer system.

albumin, hemoglobin

What two things can cause hypercalcemia?

hyperparathyroidism, cancer

Indicate two symptoms associated with uncompensated alkalosis.

tingling in nerves, light headedness

A decrease in sodium ion concentration in the blood will _________________ the release of aldosterone from the adrenal glands.

stimulate

Increased urine output occurs with _________________ ADH release.

decreased, ADH inhibits urine output

How does antidiuretic hormone (ADH) influence regulation of water output?

ADH changes the permeability of renal tubules to water

Indicate two symptoms of heatstroke.

increased heart rate, headache and dizziness

Various diseases such as cancer and hyperparathyroidism cause increased bone resorption and the subsequent imbalance called ______________________.

hypercalcemia

In the bicarbonate buffer system, _________________ can release hydrogen ions, lowering pH. To increase pH, __________________ can bind hydrogen ions, removing them from the solution.

carbonic acid; bicarbonate ions

Which situation results in a reduced urine output?

increased ADH levels in blood

When might a temporary reduction in thirst occur?

the stomach wall distends from water intake even before the water is absorbed into the blood.

Indicate two symptoms of hypocalcemia.

difficulty breathing, cardiac arrhythmias

Within the amino acids of protein molecules, the __________________ groups function as acids, whereas the _______________ groups function as bases.

carboxyl; amino

List four factors that can lead to hyperventilation and respiratory alkalosis.

aspirin poisoning, anxiety, fever, being at high altitude

The hydrostatic pressure that causes fluid to leave plasma at the arteriole end of capillaries is due to ________________.

blood pressure

Renal diseases can lead to a decrease in excretion of potassium by the kidneys, as can insufficient secretion of aldosterone. Both of these conditions can cause the ion imbalance called ___________________.

hyperkalemia

When carbon dioxide levels in the blood increase, ________________ acid production increases. This leads to an increase in hydrogen ion concentration and consequently a(n) _______________ in pH.

carbonic; decrease

Inhibiting ADH release causes ____________ water reabsorption and ___________________ urine output.

decreased; increased

What is the largest fluid compartment, containing about two-thirds of the body fluid?

intracellular fluid

Sodium is the most abundant cation in the _________________ fluid.

extracellular

The respiratory center in the brainstem will increase the breathing rate to eliminate excess carbon dioxide in order to _______________ the pH of body fluids.

increase

Two metabolic sources of hydrogen ions are _______________ and __________________.

anaerobic respiration of glucose; aerobic respiration of glucose

indicate two effects of aldosterone on the renal tubules.

increase in potassium secretion, increase in sodium reabsorption

What chemical buffer system is important for regulating hydrogen ion concentration of intracellular fluid and of tubular fluid and urine?

phosphate system

Body fluids are located within regions called ________________________, each with a potentially different composition.

composition

Drinking water decreases plasma osmolarity and ____________ the secretion of ADH.

decreases

What causes the net inward force that shifts fluid from interstitial spaces into capillaries?

colloid osmotic pressure

What is the “goal” of water movement across membranes in response to changes in sodium concentrations?

to have equal water and electrolyte concentrations inside and outside of cells

When chemical reactions in the body produce acids that accumulate in body fluids, the condition called ________________ acidosis occurs.

metabolic

Low blood levels of ________________ stimulate the release of parathyroid hormone (PTH) from the parathyroid glands.

calcium

When plasma osmolarity increases, osmoreceptors of the hypothalamus ___________ water. This change triggers nerve impulses that result in the release of ADH.

lose

When the body loses too much water, whether through excess vomiting or increased urination, a condition called _____________________ results.

dehydration

One component of the bicarbonate buffer system is ______________ acid, which acts as a weak acid.

carbonic

A decrease in sodium ion concentration in the blood will ___________________ the release of aldosterone from the adrenal glands.

stimulate

The ________________________ buffer system is present in both extracellular and intracellular body fluids.

bicarbonate

The ___________________ are able to rid the body of hydrogen ions, helping in the regulation of pH.

kidneys

List two sources of electrolytes for the body.

food and drink, metabolic reactions

INCREASED extracellular sodium causes cells to _____________. Conversely, DECREASED extracellular sodium causes cells to ______________. These changes are due to osmotic movement of water.

shrink; swell

How does alcohol consumption lead to an increase urine output?

by inhibiting the release of ADH

Receptors called _____________________ detect changes in solute concentrations of extracellular fluid.

osmoreceptors

Which type of chemical group within the amino acids of a protein can function as acids, releasing hydrogen ions when necessary?

carboxyl groups

The adrenal cortex responds to increased levels of potassium by secreting ___________________________.

aldosterone

The condition in which blood calcium levels are higher than normal is called ___________________.

hypercalcemia

The hormones ADH causes a(n) _____________________ in the permeability to water of the distal convoluted tubules and collecting ducts of the kidneys.

increase

Most of the hydrogen ions in body fluids are products of _____________________.

metabolic reactions

What enzyme is present in red blood cells and functions to convert carbon dioxide and water to carbonic acid?

carbonic anhydrase

The elimination of __________________ and ___________________ are the primary tasks of mechanisms responsible for maintaining acid-base balance.

hydrogen ions and metabolic acids

TRUE or FALSE: Sodium and potassium are the only ions that are important in cellular functions.

false

Name three sources of water loss.

water in sweat, water in urine, water in expired air

In addition to chemical buffers, acid-base balance is maintained by the excretion of carbon dioxide by the ________________ system and excretion of hydrogen ions by the _________________ system.

respiratory; urinary

Since __________________ pressure of body fluids is ordinarily stable, it is typically a change in the ___________ pressure of intracellular or extracellular fluid that causes net movement of the fluids.

hydrostatic; osmotic

Indicate nine things that include the electrolytes of greatest importance to cellular functions.

phosphate, bicarbonate, hydrogen, magnesium, chloride, sulfate, sodium, potassium, calcium

Indicate three factors that might influence the rate of water loss from the body.

relative humidity, physical exercise, temperature

A(n) _____________ helps minimize pH changes, typically by converting a strong acid or strong base to a weak one.

buffer

The _____________________ fluid compartment includes all of the fluid found within the cells of the body.

intracellular

The body can acquire sufficient electrolytes by responding to _____________ and thirst.

hunger

Substances that combine with hydrogen ions are called ____________.

bases

A ________________ base releases more hydroxide ions than a ______________ base.

strong; weak

Name three effects of parathyroid hormone.

increased calcium reabsorption from kidneys, stimulation of osteoclasts, increased calcium absorption from food

Excessive loss of carbon dioxide and subsequent loss of carbonic acid leads to _____________ alkalosis, whereas excessive loss of hydrogen ions leads to _____________ alkalosis.

respiratory; metabolic

Indicate three factors that may lead to metabolic acidosis.

kidney disease, with an inability to excrete metabolic acids, production of ketone bodies in diabetes mellitus, prolonged diarrhea, with loss of intestinal content

What term describes all of the water and electrolytes enclosed within the cells of the body?

intracellular fluid

Indicate two effects of aldosterone on the renal tubules.

increase in sodium reabsorption, increase in potassium secretion

List three symptoms of dehydration.

loss of body weight, decreased sweating, decreased urination

Control of urine volume regulates _________________.

water output

What is the importance of osmotic pressure and hydrostatic pressure in body fluid regulation?

they contribute to movement between fluid compartments

An inflammation reaction involves the release of a chemical called ______________ from damaged cells. This chemical causes capillaries to become leaky, resulting in edema.

histamine

Indicate the three major chemical buffer systems in the body.

phosphate buffer system, protein buffer system, bicarbonate buffer system

The loss of carbon dioxide, hydrogen ions, and carbonic acid that causes respiratory alkalosis develops from ________________________.

hyperventilation

The cations sodium and __________________ are important in maintaining the resting membrane potential of muscle and nervous cells.

potassium

List three mechanisms used to regulate the pH levels in body fluids.

respiratory changes, renal changes, chemical buffer systems

A patient with a brain stem injury has a decreased respiration rate and depth. The resulting acidosis is caused by ______________________.

a decreased elimination of carbon dioxide

List three electrolytes that are have high concentration levels in extracellular fluid.

sodium, chloride, bicarbonate ions

Hypoproteinemia decreases the osmotic pressure of blood plasma, __________________ the movement of interstitial fluid into the venous end of the capillary, causing edema.

decreasing

Indicate three conditions associated with thirst.

loss of water by the body, increased blood osmolarity, increased osmotic pressure of extracellular fluid

“-osis”

state, condition, or process of

“-emia”

a blood condition

“-uria”

a urine condition

Indicate three factors that can lead to respiratory acidosis.

obstruction of airways, injury to respiratory centers, reducing rate and depth of breathing, any condition that decreases gas exchange

Sulphuric acid

a product of oxidation of specific amino acids

Phosphoric acid

product of hydrolysis of nucleic acids

Carbonic acid

product of carbon dioxide (from aerobic metabolism) interacting with water

Ketone bodies

product of incomplete oxidation of fatty acids

Lactic acid

product of anaerobic metabolism

Equal quantities of base “A” and base “B” are added to separate containers that each hold an acid with pH 4. In A’s container, the pH raises to 5. In B’s container, the pH raises to 7. Which base is STRONGER?

B

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